The Indianapolis Colts upset the Green Bay Packers on Sunday with a little Luck -- Andrew Luck. The rookie quarterback topped the Colts' comeback with a four-yard pass to Reggie Wayne with 35 seconds on the clock to give them a 30-27 victory over the Packers and their first win since their coach Chuck Pagano went on a medical leave for treatment for leukemia.The Packers had a chance to tie it up, but Mason Crosby was unable to hit a 51-yard field goal with just three seconds on the clock.

In another big game, former Colts quarterback Peyton Manning was unable to lead his new team, the Denver Broncos, to victory over Tom Brady and the New England Patriots, with the Pats taking the game 31-21. Brady is now nine-and-four against Manning. He threw for 223 yards, completing 23 of 31 passes and scoring two touchdowns -- one a pass and the other a run in. Manning actually had better number, throwing for three touchdowns and 345 yards, completing 23 of 31 passes. But he also made a crucial mistake. He fumbled after being sacked in the third quarter, which led to a touchdown that put the Patriots in front 31-7.

Over in New Orleans, the Saints won their first game this season, beating the San Diego Chargers 31-24. It was also a big night for quarterback Drew Brees, who broke Johnny Unitas' by throwing a touchdown pass in 48 consecutive games.